The head of the scientific advisory board of micro-biolytics, Prof. Dr. D. Wolf, is given the ‚Landesforschungspreis 2007’. Prof. Dr. Frankenberg, Minister of Science of Baden-Württemberg presented this tribute to Prof. Wolf to honour „outstanding research results and excellent researchers“. Prof. Wolfs research on the protein degrading systems of the eukoryotic cell, the proteasome and the lysosome is regarded a breakthrough in cellular research.

In 1996 (Science 273, 1725-1728), the Wolf group discovered the retrotranslocation of a misfolded, fully glycosylated lumenal protein ( CPY* ) of the endoplasmic reticulum (ER) back into the cytoplasm and its degradation via the ubiquitin-proteasome system (ERAD). CPY* as a model substrate of ER protein quality control and degradation (ERQD) was established. The 1996 Science publication, which made a dogma fall and opened a new field of research, was considered a landmark paper of cell biology (Landmark Papers in Yeast Cell Biology, P. Linder, D. Shore and M. N. Hall, eds., pp. 273-274, Cold Spring Harbor Laboratory Press [2006]).

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In 2006, micro-biolytics was evaluated by the European Union (IRMM/EC) in BSE diagnostics: the ante mortem BSE test based on the AquaSpec™ Technology. The 100% subsidiary DiaSpec GmbH, which was founded in 2001, was accountable for the commercial and regulatory aspects of this BSE test. The results of the evaluation published in January 2007 show the great potential of the AquaSpec™ Technology in diagnostic spectroscopy: for the first time, an officially and externally evaluated spectroscopic test reached such a high performance with a diagnostic efficiency of up to 88%.

IRMM has evaluated a live animal BSE test. This is the first time such an evaluation has been made. The test was selected to enter IRMM's evaluation programme in the frame of a call for the expression of interest published by Health and Consumer Protection DG in 2003. The test of the company DiaSpec (Freiburg, DE) is based on a sophisticated method using Fourier transform infrared spectroscopy, and applies chemometric methods for data analysis. Blood serum of the animal is analysed and the spectrum obtained is compared to specific reference features of serum of BSE infected or BSE free animals... more